NOTCH3 Hamster anti-Mouse, Clone: HMN3-133, Invitrogen™

Hamster Monoclonal Antibody

Supplier:  Thermo Scientific MA528181

Catalog No. PIMA528181

Description

NOTCH3 is the third discovered human homologue of the Drosophila melanogaster type I membrane protein notch. In Drosophila, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal domit arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Specifications

• Antigen: NOTCH3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q61982
• Host Species: Hamster
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 18131
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry
• Clone: HMN3-133
• Conjugate: Unconjugated
• Gene: Notch3
• Gene Symbols: Notch3
• Immunogen: Mouse Notch 3-Fc fusion protein
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG