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Invitrogen™ NOTCH3 Monoclonal Antibody (MHN3-21), APC, eBioscience™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ 17578742

Encompass_Preferred

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Catalog No. 50-152-12


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Description

Description

Description: This MNH3-21 monoclonal antibody reacts with the extracellular domain of human Notch3, one of four members of the Notch family of receptors. Notch receptors are 300-kDa single-pass transmembrane proteins. While the extracellular domain contains numerous epidermal growth factor-like repeats for ligand binding, the intracellular domain is involved in cell signaling. Upon binding its membrane-bound ligand (either Delta or Jagged), the Notch receptor undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, heterodimerizes with the DNA-binding protein RBP-J, recruits co-activator molecules, and ultimately activates transcription. Notch3 expression has been demonstrated on some thymocyte subsets, including CD4-CD8- and CD8SP cells. This Notch receptor is also expressed on vascular smooth muscle and cells of the central nervous system. In addition to its role in stem cell hematopoiesis, Notch3 plays a pivotal role in T cell lineage commitment and thymocyte development. Moreover, Notch3 is overexpressed in human T-cell acute lymphoblastic leukemias (T-ALL) and other cancers. Finally, mutation of Notch3 has been linked to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a CNS degenerative disorder. Applications Reported: This MHN3-21 antibody has been re...

NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
TRUSTED_SUSTAINABILITY
Specifications

Specifications

NOTCH3
Monoclonal
5 μL/Test
PBS with BSA and 0.09% sodium azide; pH 7.2
Q9UM47
Notch3
Affinity chromatography
RUO
4854
4°C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
MHN3-21
APC
Notch3
AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; Neurogenic locus notch homolog protein 3; notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch gene homolog 3; Notch homolog 3; NOTCH3
Mouse
100 Tests
Primary
Human
Antibody
IgG1 κ
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