NOTCH3 Mouse anti-Human, Clone:2E4D11, Abnova™

Catalog No.	Quantity
89-334-526	100 μg

Catalog No. 89-334-526 Supplier Abnova Corporation Supplier No. MAB17841

Description

Mouse monoclonal antibody raised against recombinant human NOTCH3.

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq]

Specifications

• Antigen: NOTCH3
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 2E4D11
• Conjugate: Unconjugated
• Description: Notch homolog 3 (Drosophila)
• Dilution: ELISA (1:10000)
  Western Blot (1:100-1:500)
  The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.05% sodium azide)
• Gene: NOTCH3
• Gene Alias: CADASIL, CASIL
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 47-156 of human NOTCH3 from E. coli.
• Quantity: 100 μg
• Gene ID (Entrez): 4854
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b