Invitrogen™ NOTCH3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120855

Catalog No. PIPA5120855

Description

Positive test controls include: 293T. The target is usually found in the following locations: Cell membrane, Nucleus, Single-pass type I membrane protein. Immunogen sequence: PPEELLRSSA DFLQRLSAIL RTSLRFRLDA HGQAMVFPYH RPSPGSEPRA RRELAPEVIG SVVMLEIDNR LCLQSPENDH CFPDAQSAAD YLGALSAVER LDFPYPLRDV RGEPLEPPEP S.

NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Specifications

• Antigen: NOTCH3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Notch3
• Gene Alias: AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; Neurogenic locus notch homolog protein 3; notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch gene homolog 3; Notch homolog 3; NOTCH3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18131, 4854, 56761
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 2.35 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q61982, Q9R172, Q9UM47
• Gene Symbols: Notch3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1520-1640 of human NOTCH3 (NP_000426.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG