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Invitrogen™ NOTCH3 Polyclonal Antibody
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Catalog No. PIPA5120855
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100 μL
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PIPA5120855 100 μL
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Catalog No. PIPA5120855 Supplier Invitrogen™ Supplier No. PA5120855
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Description

Rabbit Polyclonal Antibody

Positive test controls include: 293T. The target is usually found in the following locations: Cell membrane, Nucleus, Single-pass type I membrane protein. Immunogen sequence: PPEELLRSSA DFLQRLSAIL RTSLRFRLDA HGQAMVFPYH RPSPGSEPRA RRELAPEVIG SVVMLEIDNR LCLQSPENDH CFPDAQSAAD YLGALSAVER LDFPYPLRDV RGEPLEPPEP S.

NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOTCH3
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.35 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Notch3
Gene Accession No. Q61982, Q9R172, Q9UM47
Gene Alias AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; Neurogenic locus notch homolog protein 3; notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch gene homolog 3; Notch homolog 3; NOTCH3
Gene Symbols Notch3
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18131, 4854, 56761
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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