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Invitrogen™ NOTCH3 Polyclonal Antibody
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Catalog No. PIPA547120
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100 μg
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Catalog No. Quantity
PIPA547120 100 μg
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Catalog No. PIPA547120 Supplier Invitrogen™ Supplier No. PA547120
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Description

Goat Polyclonal Antibody

In direct ELISAs, less than 10% cross-reactivity with recombinant human Notch-3 is observed and less than 5% cross-reactivity with recombinant rat (rr) Notch-1 and rrNotch-2 is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOTCH3
Applications Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Neutralization, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Notch3
Gene Accession No. Q61982
Gene Alias AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; Neurogenic locus notch homolog protein 3; notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch gene homolog 3; Notch homolog 3; NOTCH3
Gene Symbols Notch3
Host Species Goat
Immunogen Sf 21-derived recombinant mouse Notch-3 Ala40-Glu468.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18131
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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