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Invitrogen™ NOTCH3 Recombinant Rabbit Monoclonal Antibody (4H5L17)

Catalog No. PI701975
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Catalog No. Quantity
PI701975 100 μg
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Catalog No. PI701975 Supplier Invitrogen™ Supplier No. 701975
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Bovine, Rat, Cat Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOTCH3
Applications Western Blot
Classification Recombinant Monoclonal
Clone 4H5L17
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene Notch3
Gene Accession No. Q9UM47
Gene Alias AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; Neurogenic locus notch homolog protein 3; notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch gene homolog 3; Notch homolog 3; NOTCH3
Gene Symbols Notch3
Host Species Rabbit
Immunogen Peptides corresponding to human Notch3 (aa2308-2321, 1618-1636, 1803-1816).
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4854
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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