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Invitrogen™ NOTUM Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520788

Catalog No. PIPA520788


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Description

Description

A suggested positive control is human kidney tissue lysate. PA5-20788 can be used with blocking peptide PEP-0902.

Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the a/beta-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

NOTUM
Polyclonal
Unconjugated
NOTUM
[Wnt protein] O-palmitoleoyl-L-serine hydrolase; 5730593N15Rik; hNOTUM; NOTUM; notum pectinacetylesterase homolog; notum pectinacetylesterase homolog (Drosophila); NOTUM, palmitoleoyl-protein carboxylesterase; OK/SW-CL.30; Palmitoleoyl-protein carboxylesterase NOTUM; protein notum homolog; RGD1307119
Rabbit
Antigen affinity chromatography
RUO
147111, 303743, 77583
Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Liquid
Immunohistochemistry, Western Blot, Immunocytochemistry
1 mg/mL
PBS with 0.02% sodium azide
Q6P988, Q8R116
NOTUM
A 19 amino acid peptide near the amino terminus of human NOTUM.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
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