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Invitrogen™ NOTUM Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA520788
Description
A suggested positive control is human kidney tissue lysate. PA5-20788 can be used with blocking peptide PEP-0902.
Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the a/beta-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.
Specifications
NOTUM | |
Polyclonal | |
Unconjugated | |
NOTUM | |
[Wnt protein] O-palmitoleoyl-L-serine hydrolase; 5730593N15Rik; hNOTUM; NOTUM; notum pectinacetylesterase homolog; notum pectinacetylesterase homolog (Drosophila); NOTUM, palmitoleoyl-protein carboxylesterase; OK/SW-CL.30; Palmitoleoyl-protein carboxylesterase NOTUM; protein notum homolog; RGD1307119 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
147111, 303743, 77583 | |
Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C | |
Liquid |
Immunohistochemistry, Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
Q6P988, Q8R116 | |
NOTUM | |
A 19 amino acid peptide near the amino terminus of human NOTUM. | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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