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Invitrogen™ NOTUM Polyclonal Antibody
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Catalog No. PIPA5113025
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100 μg
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PIPA5113025 100 μg
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Catalog No. PIPA5113025 Supplier Invitrogen™ Supplier No. PA5113025
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Description

Rabbit Polyclonal Antibody

NOTUM Polyclonal Antibody for Western Blot, ELISA

Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the a/beta-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOTUM
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.65 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% ProClin 300, 0.02% sodium azide; pH 7.4
Gene NOTUM
Gene Accession No. Q6P988, Q8R116
Gene Alias [Wnt protein] O-palmitoleoyl-L-serine hydrolase; 5730593N15Rik; hNOTUM; NOTUM; notum pectinacetylesterase homolog; notum pectinacetylesterase homolog (Drosophila); NOTUM, palmitoleoyl-protein carboxylesterase; OK/SW-CL.30; Palmitoleoyl-protein carboxylesterase NOTUM; protein notum homolog; RGD1307119
Gene Symbols NOTUM
Host Species Rabbit
Immunogen Recombinant Human Palmitoleoyl-protein carboxylesterase NOTUM protein (100-235AA).
Purification Method Antigen Affinity Chromatography, Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 147111, 77583
Target Species Human, Mouse
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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