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Invitrogen™ NOV Polyclonal Antibody
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Catalog No. PIPA547174
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100 μg
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Catalog No. Quantity
PIPA547174 100 μg
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Catalog No. PIPA547174 Supplier Invitrogen™ Supplier No. PA547174
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Description

Goat Polyclonal Antibody

In sandwich ELISAs, approximately 7% cross-reactivity with recombinant mouse NOV/CCN3 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

NOV is a member of the CCN family of secreted, cysteine-rich regulatory proteins. The full-length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm's tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorigenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell-surface integrins, and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOV
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene CCN3
Gene Accession No. P48745
Gene Alias C130088N23Rik; CCN family member 3; CCN3; Cellular communication network factor 3; IBP-9; IGF-binding protein 9; IGFBP9; IGFBP-9; Insulin-like growth factor-binding protein 9; Nephro blastoma-overexpressed gene protein homolog; nephroblastoma overexpressed; nephroblastoma overexpressed gene; nephroblastoma overexpressed gene protein homolog; nephroblastoma-overexpressed gene protein homolog; NOV; NovH; protein NOV homolog
Gene Symbols CCN3
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant human NOV/CCN3 Thr32-Met357.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4856
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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