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Invitrogen™ NOX2 Polyclonal Antibody
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Catalog No. PIPA5114489
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100 μg
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PIPA5114489 100 μg
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Catalog No. PIPA5114489 Supplier Invitrogen™ Supplier No. PA5114489
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Description

Rabbit Polyclonal Antibody

Positive controls that may be used include: Rat Brain Tissue Lysate.

Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase complex expresses in phagocytes, neuroepithelial bodies, vascular smooth muscle cells, and endothelial cells. It includes a membrane bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. Mox1 and gp91 contain identical C-terminal sequence identity, yet possess distinct expression patterns. gp91-phox expresses in eosinophils, neutrophils, monocytes, and B-lymphocytes, whereas Mox1 is predominantly detected in the colon, with low expression in the uterus and prostate.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOX2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Cybb
Gene Accession No. P04839, Q61093
Gene Alias AMCBX2; C88302; Cgd; CGD91-phox; Cybb; Cyd; cytochrome b(558) subunit beta; cytochrome b-245 beta chain; cytochrome b-245 beta polypeptide; cytochrome b-245 heavy chain; cytochrome b-245, beta polypeptide; cytochrome b558 subunit beta; endothelial type gp91-phox; GP91 PHOX; GP911; GP91-1; GP91PHOX; gp91-phox; Heme-binding membrane glycoprotein gp91phox; IMD34; NADPH oxidase 2; neutrophil cytochrome b 91 kDa polypeptide; Nox2; p22 phagocyte B-cytochrome; p91PHOX; p91-PHOX; superoxide-generating NADPH oxidase heavy chain subunit
Gene Symbols Cybb
Host Species Rabbit
Immunogen Rabbit polyclonal NOX2 antibody was raised against a 15 amino acid peptide near the amino terminus of human NOX2. The immunogen is located within amino acids 140 - 190 of NOX2.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13058, 1536, 66021
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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