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Invitrogen™ NOX4 Polyclonal Antibody
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Catalog No. PIPA572816
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100 μg
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Catalog No. Quantity
PIPA572816 100 μg
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Catalog No. PIPA572816 Supplier Invitrogen™ Supplier No. PA572816
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Description

Rabbit Polyclonal Antibody

NOX4 Polyclonal Antibody for ELISA, IHC (P), Western Blot

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOX4
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Nox4
Gene Accession No. Q924V1, Q9JHI8, Q9NPH5
Gene Alias AI648021; kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX; KOX1; KOX-1; NADPH oxidase 4; NOX 4; NOX4; NOX-4; renal NAD(P)H-oxidase; RENOX; superoxide-generating NADPH oxidase 4
Gene Symbols Nox4
Host Species Rabbit
Immunogen NOX4 antibody for a 14 amino acid peptide near the amino terminus of human NOX4. The immunogen is within amino acids 70 - 120 of NOX4.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 50490, 50507, 85431
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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