Invitrogen™ NOX4 Recombinant Rabbit Monoclonal Antibody (2B2K7)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA551408

Catalog No. FEMA551408

Description

Immunogen sequence: LHNKFWQENR PDYVNIQLYL SQTDGIQKII GEKYHALNSR LFIGRPRWKL LFDEIAKYNR GKTVGVFCCG PNSLSKTLHK LSNQNNSYGT RFEYNKESFS.

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.

Specifications

• Antigen: NOX4
• Classification: Recombinant Monoclonal
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q924V1, Q9JHI8, Q9NPH5
• Gene Symbols: Nox4
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 479-578 of human NADPH oxidase 4 (NOX4) (NP_058627.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Format: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 2B2K7
• Conjugate: Unconjugated
• Gene: Nox4
• Gene Alias: AI648021; kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX; KOX1; KOX-1; NADPH oxidase 4; NOX 4; NOX4; NOX-4; renal NAD(P)H-oxidase; RENOX; superoxide-generating NADPH oxidase 4
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 50490, 50507, 85431
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Isotype: IgG