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Invitrogen™ NOX4 Recombinant Rabbit Monoclonal Antibody (2B2K7)
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Catalog No. FEMA551408
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100 μL
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FEMA551408 100 μL
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Catalog No. FEMA551408 Supplier Invitrogen™ Supplier No. MA551408
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: LHNKFWQENR PDYVNIQLYL SQTDGIQKII GEKYHALNSR LFIGRPRWKL LFDEIAKYNR GKTVGVFCCG PNSLSKTLHK LSNQNNSYGT RFEYNKESFS.

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOX4
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone 2B2K7
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Nox4
Gene Accession No. Q924V1, Q9JHI8, Q9NPH5
Gene Alias AI648021; kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX; KOX1; KOX-1; NADPH oxidase 4; NOX 4; NOX4; NOX-4; renal NAD(P)H-oxidase; RENOX; superoxide-generating NADPH oxidase 4
Gene Symbols Nox4
Host Species Rabbit
Immunogen Synthetic peptide.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 50490, 50507, 85431
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG
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