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Invitrogen™ NOXA Monoclonal Antibody (114C307.1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA141000

Catalog No. 01-676-429


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Description

Description

Suggested positive control: antigen standard for PMAIP1 (transient overexpression lysate), RL-7, Jurkat.

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

NOXA
Monoclonal
1.0 mg/mL
PBS with 0.05% sodium azide
Q13794, Q5U777, Q9JM54
PMAIP1
Human Noxa.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG1 κ
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
114C307.1
Unconjugated
PMAIP1
adult T cell leukemia-derived PMA-responsive; APR; Immediate-early-response protein APR; Noxa; Phorbol-12-myristate-13-acetate-induced protein 1; PMA-ind; PMA-induced protein 1; Pmaip1; Protein Noxa
Mouse
Protein G
RUO
492821, 5366, 58801
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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