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Invitrogen™ NOXA Monoclonal Antibody (114C307.1)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA141000
Description
Suggested positive control: antigen standard for PMAIP1 (transient overexpression lysate), RL-7, Jurkat.
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.
Specifications
NOXA | |
Monoclonal | |
1.0 mg/mL | |
PBS with 0.05% sodium azide | |
Q13794, Q5U777, Q9JM54 | |
PMAIP1 | |
Human Noxa. | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG1 κ |
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
114C307.1 | |
Unconjugated | |
PMAIP1 | |
adult T cell leukemia-derived PMA-responsive; APR; Immediate-early-response protein APR; Noxa; Phorbol-12-myristate-13-acetate-induced protein 1; PMA-ind; PMA-induced protein 1; Pmaip1; Protein Noxa | |
Mouse | |
Protein G | |
RUO | |
492821, 5366, 58801 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
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