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Invitrogen™ NOXA Polyclonal Antibody
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Catalog No. PIPA597244
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100 μL
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PIPA597244 100 μL
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Catalog No. PIPA597244 Supplier Invitrogen™ Supplier No. PA597244
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MPGKKARKNA QPSPARAPAE LEVECATQLR RFGDKLNFRQ KLLNLISKLF CSGT; Positive Samples: Jurkat, HeLa, HT-1080, SKOV3, BT-474; Cellular Location: Mitochondrion.

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOXA
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.88 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PMAIP1
Gene Accession No. Q13794, Q5U777, Q9JM54
Gene Alias adult T cell leukemia-derived PMA-responsive; APR; Immediate-early-response protein APR; Noxa; Phorbol-12-myristate-13-acetate-induced protein 1; PMA-ind; PMA-induced protein 1; Pmaip1; Protein Noxa
Gene Symbols PMAIP1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-54 of human PMAIP1 (NP_0669501).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 492821, 5366, 58801
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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