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Invitrogen™ NPHP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA561148

Catalog No. PIPA561148


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Description

Description

Immunogen sequence: TVEDTNGSET GFRAWNVQSR GRIFLVSKPV LQINTVDVLT TMGAIPAGFR PSTLSQLLEE GNQFRANYFL QPELMPSQLA FRDLMWDATE GTIRSRPS Highest antigen sequence identity to the following orthologs: Mouse - 59%, Rat - 57%.

Juvenile nephronophthisis type 1 is caused by mutations of NPHP1, the gene encoding for nephrocystin. Nephrocystin interacts with p130Cas (BCAR1), proline-rich tyrosine kinase-2 (PTK2B or Pyk2), and tensin in embryonic kidney and testis, indicating that these proteins participate in a common signaling pathway. Nephrocystin and p130Cas interact in mammalian cells and both proteins prominently localize at or near sites of cell-cell contact in polarized Madin-Darby canine kidney epithelial cells. Expression of nephrocystin results in phosphorylation of Pyk2 on Tyrosine 402 as well as activation of downstream mitogen-activated protein kinases, such as ERK1 and ERK2. Nephrocystin contains a src-homology 3 (SH3) domain, which is highly conserved throughout evolution.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

NPHP1
Polyclonal
Unconjugated
NPHP1
JBTS4; juvenile nephronophthisis 1 protein; nephrocystin 1; Nephrocystin1; nephrocystin-1; nephronophthisis 1 (juvenile); nephronophthisis 1 (juvenile) homolog; nephronophthisis 1 (juvenile) homolog (human); NPH1; NPHP1; SLSN1
Rabbit
Antigen affinity chromatography
RUO
4867
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin)
0.1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
O15259
NPHP1
Recombinant protein corresponding to Human NPHP1. Recombinant protein control fragment (Product #RP-96114).
100 μL
Primary
Human
Antibody
IgG
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