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Invitrogen™ NPHP1 Polyclonal Antibody
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Catalog No. PIPA125150
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Quantity:
50 μg
Catalog No. Quantity
PIPA125150 50 μg
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Catalog No. PIPA125150

Supplier: Invitrogen™ PA125150

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Description

Rabbit Polyclonal Antibody

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Juvenile nephronophthisis type 1 is caused by mutations of NPHP1, the gene encoding for nephrocystin. Nephrocystin interacts with p130Cas (BCAR1), proline-rich tyrosine kinase-2 (PTK2B or Pyk2), and tensin in embryonic kidney and testis, indicating that these proteins participate in a common signaling pathway. Nephrocystin and p130Cas interact in mammalian cells and both proteins prominently localize at or near sites of cell-cell contact in polarized Madin-Darby canine kidney epithelial cells. Expression of nephrocystin results in phosphorylation of Pyk2 on Tyrosine 402 as well as activation of downstream mitogen-activated protein kinases, such as ERK1 and ERK2. Nephrocystin contains a src-homology 3 (SH3) domain, which is highly conserved throughout evolution.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NPHP1
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene NPHP1
Gene Accession No. Q9QY53
Gene Alias JBTS4; juvenile nephronophthisis 1 protein; nephrocystin 1; Nephrocystin1; nephrocystin-1; nephronophthisis 1 (juvenile); nephronophthisis 1 (juvenile) homolog; nephronophthisis 1 (juvenile) homolog (human); NPH1; NPHP1; SLSN1
Gene Symbols NPHP1
Host Species Rabbit
Immunogen GST fusion protein corresponding to amino acids 612-691 of mouse NPHP1.
Purification Method IgG fraction
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 53885
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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