NPHP3 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Catalog No.	Quantity
50-558-651	150 μL

Catalog No. 50-558-651 Supplier Proteintech Group Inc Supplier No. 220261AP150UL

Description

Rabbit Polyclonal Antibody

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3′ end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3′ end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Specifications

• Antigen: NPHP3
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.51 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: NPHP3
• Gene Accession No.: Q7TNH6, Q7Z494
• Gene Alias: KIAA2000, MKS7, Nephrocystin 3, NPHP3
• Gene Symbols: Nphp3
• Host Species: Rabbit
• Immunogen: NPHP3 Fusion Protein Ag16888
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 27031, 74025
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG