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NPM1 Antibody (NPM1/3286), PE, Novus Biologicals™
SDP

Catalog No. NB011599 Shop All R&D Systems Products
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NB011599 0.1 mL
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Catalog No. NB011599 Supplier Novus Biologicals Supplier No. NBP279875PE
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Description

Mouse Monoclonal Antibody

NPM1 Monoclonal specifically detects NPM1 in Human samples. It is validated for Flow Cytometry.

Specifications

Antigen NPM1
Applications Flow Cytometry
Classification Monoclonal
Clone NPM1/3286
Conjugate PE
Dilution Flow Cytometry
Formulation PBS with 0.05% Sodium Azide
Gene Alias B23, MGC104254, NPMnucleophosmin/nucleoplasmin family, member 1, Nucleolar phosphoprotein B23, Nucleolar protein NO38, nucleophosmin, nucleophosmin (nucleolar phosphoprotein B23, numatrin), numatrin
Gene Symbols NPM1
Host Species Mouse
Immunogen Recombinant human NPM1 protein fragment (aa185-287) (exact sequence is proprietary) (Uniprot: P06748)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Apoptosis, Cancer, Cell Cycle and Replication, Chromatin Research, DNA replication Transcription Translation and Splicing, Mitotic Regulators, Phospho Specific, Signal Transduction, Tumor Suppressors
Primary or Secondary Primary
Test Specificity Recognizes a 33kDa glycoprotein, identified as NPM1 (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia. The antibody may be a useful aid for classification of acute myeloid leukemia.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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