NR0B2 Monoclonal Antibody (OTI1A2), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA806268

Catalog No. 50-168-1042

Description

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

Specifications

• Antigen: NR0B2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q15466
• Gene Symbols: NR0B2
• Immunogen: Full length human recombit protein of human NR0B2 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI1A2
• Conjugate: Unconjugated
• Gene: NR0B2
• Gene Alias: SHP, SHP1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8431
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid