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Invitrogen™ NR0B2 Monoclonal Antibody (OTI5F10)
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Catalog No. PIMA526785
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100 μL
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PIMA526785 100 μL
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Catalog No. PIMA526785 Supplier Invitrogen™ Supplier No. MA526785
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Description

Mouse Monoclonal Antibody

NR0B2 Monoclonal Antibody for Western Blot, IHC (P)

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NR0B2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI5F10
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene NR0B2
Gene Accession No. Q15466
Gene Alias Nr0b2; Nr0b2a; nuclear receptor SHP; nuclear receptor subfamily 0 group B member 2; nuclear receptor subfamily 0, group B, member 2; orphan nuclear receptor SHP; SHP; SHP1; SHP-1; small heterodimer partner; small heterodimer partner homologue
Gene Symbols NR0B2
Host Species Mouse
Immunogen Full length human recombinant protein of NR0B2 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8431
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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