NR0B2 Monoclonal Antibody (OTI8E5), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-1081	100 μL

Catalog No. 50-168-1081 Supplier OriGene Supplier No. TA806345

Description

Mouse Monoclonal Antibody

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

Specifications

• Antigen: NR0B2
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI8E5
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: NR0B2
• Gene Accession No.: Q15466
• Gene Alias: SHP, SHP1
• Gene Symbols: NR0B2
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human NR0B2 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8431
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1