Invitrogen™ NR0B2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA533995

Catalog No. PIPA533995

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Hamster, Rabbit (100%) Rat, Bovine, Bat (94%).

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

Specifications

• Antigen: NR0B2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NR0B2
• Gene Alias: Nr0b2; Nr0b2a; nuclear receptor SHP; nuclear receptor subfamily 0 group B member 2; nuclear receptor subfamily 0, group B, member 2; orphan nuclear receptor SHP; SHP; SHP1; SHP-1; small heterodimer partner; small heterodimer partner homologue
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100357662, 100769023, 23957, 8431
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: Q15466, Q62227
• Gene Symbols: NR0B2
• Immunogen: Synthetic 16 amino acid peptide from ligand-binding domain of human NR0B2.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rabbit, Monkey, Hamster
• Product Type: Antibody
• Isotype: IgG