NR1I3 Mouse anti-Human, Clone: OTI1C6, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF805312

Catalog No. 50-166-7373

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: NR1I3
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: NR1I3
• Gene Alias: CAR, CAR1, MB67
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9970
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1C6
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q14994
• Gene Symbols: NR1I3
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-236 of human NR1I3 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1