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Invitrogen™ NRCAM Monoclonal Antibody (N364/51), FITC
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Catalog No. PIMA545682
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100 μg
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PIMA545682 100 μg
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Catalog No. PIMA545682 Supplier Invitrogen™ Supplier No. MA545682
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Description

Mouse Monoclonal Antibody

Rat: 96% identity (795/822 amino acids identical). Human: 91% identity (753/822 amino acids identical) ~50% identity with Neurofascin. 1 μg/mL of MA5-45682 was sufficient for detection of NrCAM in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 160kDa. This antibody was formerly sold as clone S364-51.

Neuron-glia-related cell adhesion molecule (NRCAM) is a gene located on chromosome 7q31.1, encoding a protein that belongs to the immunoglobulin superfamily of cell adhesion molecules. NRCAM is expressed in the nervous system and plays a vital role in the development and maintenance of neural connections. This adhesion molecule facilitates neuron-neuron and neuron-glia interactions, impacting processes such as axon guidance, synapse formation, and cell signaling, which are crucial for neural development and plasticity. NRCAM is involved in the modulation of signal transduction pathways that influence neuronal growth and repair, contributing to the stabilization of synaptic structures. Alterations in NRCAM expression or function have been linked to neurodevelopmental disorders, including autism spectrum disorders, and certain psychiatric conditions, reflecting its importance in maintaining neural circuit integrity. Research into NRCAM continues to explore its therapeutic potential in neurobiology and its implications in neurological and psychiatric disorders.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NRCAM
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N364/51
Concentration 1 mg/mL
Conjugate FITC
Formulation PBS, 9.09mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
Gene NRCAM
Gene Accession No. P97686, Q810U4, Q92823
Gene Alias ankyrin-binding cell adhesion molecule NrCAM; Bravo; C030017F07Rik; C130076O07Rik; hBravo; KIAA0343; mBravo; MGC138845; MGC138846; mKIAA0343; neuronal cell adhesion molecule; Neuronal surface protein Bravo; neuron-glia-CAM-related cell adhesion molecule; ng-CAM-related; NgCAM-related cell adhesion molecule; Nr CAM; Nrcam; nr-CAM; rBravo
Gene Symbols NRCAM
Host Species Mouse
Immunogen Fusion protein amino acids 30-845 (extracellular domain) of mouse NrCAM.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 319504, 4897, 497815
Target Species Human, Mouse, Rat
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG2a
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