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Invitrogen™ NRG3 Polyclonal Antibody
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Catalog No. PIPA542602
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100 μL
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PIPA542602 100 μL
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Catalog No. PIPA542602 Supplier Invitrogen™ Supplier No. PA542602
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Description

Rabbit Polyclonal Antibody

Peptide sequence: TSINMQLPSR ETNPYFNSLE QKDLVGYSST RASSVPIIPS VGLEETCLQM Sequence homology: Cow: 93%; Dog: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%.

This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3. NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NRG3
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene NRG3
Gene Accession No. P56975
Gene Alias HGNC:7999; HRG3; neuregulin 3; neuregulin 3 variant 1; neuregulin 3 variant 10; neuregulin 3 variant 11; neuregulin 3 variant 12; neuregulin 3 variant 13; neuregulin 3 variant 14; neuregulin 3 variant 3; neuregulin 3 variant 4; neuregulin 3 variant 5; neuregulin 3 variant 6; neuregulin 3 variant 7; neuregulin 3 variant 8; neuregulin 3 variant 9; Neuregulin-3; neuregulin-3-like polypeptide; NRG3; NRG-3; Pro-neuregulin-3, membrane-bound isoform; pro-NRG3; RGD1559678; scaramanga; ska
Gene Symbols NRG3
Host Species Rabbit
Immunogen Synthetic peptide directed towards the middle region of human NRG3.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10718
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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