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Invitrogen™ NRG3 Recombinant Rabbit Monoclonal Antibody (6V9X1)
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Catalog No. PIMA537986
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PIMA537986 100 μL
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Catalog No. PIMA537986 Supplier Invitrogen™ Supplier No. MA537986
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: SH-SY5Y, U-251MG, C6, Mouse brain, Rat brain Immunogen sequence: IIPSVGLEET CLQMPGISEV KSIKWCKNSY SADVVNVSIP VSDCLIAEQQ EVKILLETVQ EQIRILTDAR RSEDYELASV ETEDSASENT AFLPLSPTAK SEREAQFVLR NEIQRDSALT K.

This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3. NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NRG3
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 6V9X1
Concentration 0.35 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene NRG3
Gene Accession No. O35181, P56975
Gene Alias HGNC:7999; HRG3; neuregulin 3; neuregulin 3 variant 1; neuregulin 3 variant 10; neuregulin 3 variant 11; neuregulin 3 variant 12; neuregulin 3 variant 13; neuregulin 3 variant 14; neuregulin 3 variant 3; neuregulin 3 variant 4; neuregulin 3 variant 5; neuregulin 3 variant 6; neuregulin 3 variant 7; neuregulin 3 variant 8; neuregulin 3 variant 9; Neuregulin-3; neuregulin-3-like polypeptide; NRG3; NRG-3; Pro-neuregulin-3, membrane-bound isoform; pro-NRG3; RGD1559678; scaramanga; ska
Gene Symbols NRG3
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 600-720 of human Neuregulin-3 (Neuregulin-3 (NRG3)) (P56975).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10718, 18183, 498596
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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