Invitrogen™ NRG4 Monoclonal Antibody (C2)

Catalog No.	Quantity
PIMA541647	200 μL
PIMA543644	20 μL

Catalog No. PIMA541647

Supplier: Invitrogen™ MA541647

Description

Mouse Monoclonal Antibody

NRG4 Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

Neuregulin 4 (NRG4) is a member of the Neuregulin family serving as a ligand for the epidermal growth factor receptor (EGFR) family, specifically interacting with ERBB4. This gene is primarily expressed in brown adipose tissue and liver, where it plays a pivotal role in metabolic regulation. NRG4 acts as a critical signaling molecule in adipose tissue, promoting systemic glucose homeostasis and energy expenditure while inhibiting hepatic lipogenesis, thereby contributing to protection against diet-induced obesity and insulin resistance. Moreover, NRG4 expression is inversely correlated with adiposity and positively correlated with insulin sensitivity, suggesting its potential role in metabolic homeostasis. Studies reveal that NRG4's interaction with ERBB4 stimulates specific cellular pathways, which can impact hepatic gluconeogenesis, underscoring its importance in glucose metabolism. Additionally, NRG4 has been linked to breast cancer progression, where it contributes to tumor cell survival through signaling pathways involving receptor tyrosine kinases. Due to its significant involvement in metabolic pathways and cancer biology, NRG4 is considered a promising target for therapeutic intervention in metabolic disorders and certain cancers.

Specifications

• Antigen: NRG4
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: C2
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene: NRG4
• Gene Accession No.: Q8WWG1
• Gene Alias: AI552600; heregulin 4; HRG4; neuregulin 4; Neuregulin-4; NRG4; NRG-4; Pro-neuregulin-4, membrane-bound isoform; pro-NRG4
• Gene Symbols: NRG4
• Host Species: Mouse
• Immunogen: Recombinant protein Neuregulin 4. The antigen corresponds to amino acid range 1-62 of the target protein.
• Purification Method: Protein A/G
• Quantity: 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 145957
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a κ