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Invitrogen™ NRG4 Polyclonal Antibody
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Catalog No. PIPA5102641
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PIPA5102641 100 μL
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Catalog No. PIPA5102641 Supplier Invitrogen™ Supplier No. PA5102641
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total NRG4.

Neuregulin 4 (NRG4) is a member of the Neuregulin family serving as a ligand for the epidermal growth factor receptor (EGFR) family, specifically interacting with ERBB4. This gene is primarily expressed in brown adipose tissue and liver, where it plays a pivotal role in metabolic regulation. NRG4 acts as a critical signaling molecule in adipose tissue, promoting systemic glucose homeostasis and energy expenditure while inhibiting hepatic lipogenesis, thereby contributing to protection against diet-induced obesity and insulin resistance. Moreover, NRG4 expression is inversely correlated with adiposity and positively correlated with insulin sensitivity, suggesting its potential role in metabolic homeostasis. Studies reveal that NRG4's interaction with ERBB4 stimulates specific cellular pathways, which can impact hepatic gluconeogenesis, underscoring its importance in glucose metabolism. Additionally, NRG4 has been linked to breast cancer progression, where it contributes to tumor cell survival through signaling pathways involving receptor tyrosine kinases. Due to its significant involvement in metabolic pathways and cancer biology, NRG4 is considered a promising target for therapeutic intervention in metabolic disorders and certain cancers.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NRG4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene NRG4
Gene Accession No. Q8WWG1, Q9WTX4
Gene Alias AI552600; heregulin 4; HRG4; neuregulin 4; Neuregulin-4; NRG4; NRG-4; Pro-neuregulin-4, membrane-bound isoform; pro-NRG4
Gene Symbols NRG4
Host Species Rabbit
Immunogen A synthesized peptide derived from human NRG4(Accession Q8WWG1), corresponding to amino acid residues L82-H115.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 145957, 690919, 83961
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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