Invitrogen™ NRXN3 Polyclonal Antibody

Catalog No.	Quantity
PIPA547714	100 μg

Catalog No. PIPA547714 Supplier Invitrogen™ Supplier No. PA547714

Description

Sheep Polyclonal Antibody

In direct ELISAs, approximately 10% cross-reactivity with recombinant human Neurexin 1 beta is observed and less than 5% cross-reactivity recombinant rat (rr) Neurexin 1 alpha and rrNeurexin 2 beta is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Neurexins comprise a family of neuronal cell surface proteins, which include neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3) and Caspr (neurexin IV). Neurexins I-III are expressed as a and b isoforms. The a isoforms are made of three cassettes, which contain two LNS (Laminin A, Neurexins, Sex hormone-binding)-domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal. The a isoforms bind to neurexophilins at the second LNS site and to the excitatory neurotoxin a-latrotoxin. The b isoforms have only one LNS-domain, bind to neuroligins, and play a role in the formation and remodeling of synapes. Caspr (for Contactin-Associated Protein 1, also designated Paranodin in mouse), contains an extracellular domain similar to the other three neurexins, and binds to the surface glycoprotein Contactin. Caspr and the closely related Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. Specifically, Caspr exists at the paranodal junctions, while Caspr2 colocalizes with Shaker-like K+ channels in the juxtaparanodal region. Caspr may play a role in the communication of glial cells and neurons during development.

Specifications

• Antigen: NRXN3
• Applications: Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: NRXN3
• Gene Accession No.: Q6P9K9, Q9HDB5, Q9Y4C0
• Gene Alias: C14orf60; KIAA0743; neurexin 3; Neurexin 3alpha; neurexin III; Neurexin III-alpha; Neurexin III-beta; Neurexin-3; neurexin-3-alpha; Neurexin-3-beta; Neurexin-3-beta, C-terminal fragment; Neurexin-3-beta, soluble form; Nrxn3; NRXN3-CTF
• Gene Symbols: NRXN3
• Host Species: Sheep
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Neurexin 3/NRXN3 Ser35-Thr357.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18191, 9369
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG