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Invitrogen™ NRXN3 Polyclonal Antibody
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Catalog No. PIPA5116301
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400 μL
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PIPA5116301 400 μL
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Catalog No. PIPA5116301 Supplier Invitrogen™ Supplier No. PA5116301
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Description

Rabbit Polyclonal Antibody

NRXN3 Polyclonal Antibody for Western Blot

Neurexins comprise a family of neuronal cell surface proteins, which include neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3) and Caspr (neurexin IV). Neurexins I-III are expressed as a and b isoforms. The a isoforms are made of three cassettes, which contain two LNS (Laminin A, Neurexins, Sex hormone-binding)-domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal. The a isoforms bind to neurexophilins at the second LNS site and to the excitatory neurotoxin a-latrotoxin. The b isoforms have only one LNS-domain, bind to neuroligins, and play a role in the formation and remodeling of synapes. Caspr (for Contactin-Associated Protein 1, also designated Paranodin in mouse), contains an extracellular domain similar to the other three neurexins, and binds to the surface glycoprotein Contactin. Caspr and the closely related Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. Specifically, Caspr exists at the paranodal junctions, while Caspr2 colocalizes with Shaker-like K+ channels in the juxtaparanodal region. Caspr may play a role in the communication of glial cells and neurons during development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NRXN3
Applications Western Blot
Classification Polyclonal
Concentration 0.26 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene NRXN3
Gene Accession No. Q9HDB5, Q9Y4C0
Gene Alias C14orf60; KIAA0743; neurexin 3; Neurexin 3alpha; neurexin III; Neurexin III-alpha; Neurexin III-beta; Neurexin-3; neurexin-3-alpha; Neurexin-3-beta; Neurexin-3-beta, C-terminal fragment; Neurexin-3-beta, soluble form; Nrxn3; NRXN3-CTF
Gene Symbols NRXN3
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 436-462 amino acids from the C-terminal region of human NRXN3.
Purification Method Antigen affinity chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9369
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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