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Tocris Bioscience™ NS 383

Catalog No. 592710
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59-271-0 10 mg
59-275-0 50 mg
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Catalog No. 59-271-0 Supplier Tocris Bioscience™ Supplier No. 5927/10
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Description

ASIC blocker; active in vivo

NS 383 is an ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.

Specifications

Chemical Name or Material 8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1 H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime
CAS 309711-59-9
Quantity 10 mg
Target Acid-sensing Ion Channel Blockers
Molecular Formula C19H19N3O2
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