Tocris™ NS 9283

Positive allosteric modulator of alpha4beta2

Manufacturer: Tocris™ 5112/50

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Catalog No. 51-125-0

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Disclaimers:

For Research Use Only


    Specifications

    Product Type NS 9283
    Inhibitors NS 9283
    Purity >99
    Molecular Weight 248.24
    Quantity 50mg

    Positive allosteric modulator of α4β2 receptor; increases the potency of Ach-evoked currents ~60 fold without effecting the maximum efficacy (HEK293-hα4β2 cells). Reduces the rate of recovery from desensitization and slows the rate of deactivation. Displays a synergistic effect on the Emax when given with NS206 at 3α:2β receptors.

    • Chemical Name: 3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile
    • Formula: C14H8N4O
    • CAS Number: 913830-15-6
    • Solubility: Soluble to 50mM in DMSO and to 20mM in 1eq. HCl
    • Purity: >99

  • Description & Specifications

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