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  6. NSC 109555 ditosylate, Tocris Bioscience™

NSC 109555 ditosylate, Tocris Bioscience™

Catalog No. 303450
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective Chk2 inhibitor

Selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM). Inhibits histone H1 phosphorylation (IC50 = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo.

Chemical Identifiers

CAS 66748-43-4
Molecular Formula C33H40N10O7S2
Molecular Weight (g/mol) 752.866
InChI Key DIQGNVANOSOABS-UHFFFAOYSA-N
Synonym 2,2'-carbonylbis azanediyl bis 4,1-phenylene bis ethan-1-yl-1-ylidene bis hydrazinecarboximidamide 4-methylbenzenesulfonate
PubChem CID 118797492
IUPAC Name 1,3-bis[4-[N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]urea;4-methylbenzenesulfonic acid
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CC(=NN=C(N)N)C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)C(=NN=C(N)N)C

Specifications

Quantity 50 mg
Formula Weight 752.86
Percent Purity >98%
Chemical Name or Material NSC 109555 ditosylate

Safety and Handling

Recommended Storage Store at -20°C
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