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NSD1 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501571354
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50-157-1354 10 μL
50-157-1353 100 μL
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Catalog No. 50-157-1354 Supplier Bethyl Laboratories, Inc Supplier No. IHC00027T
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Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

Specifications

Antigen NSD1
Applications Immunohistochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene NSD1
Gene Accession No. Q96L73
Gene Alias Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Androgen receptor coactivator 267 kDa protein, Androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, Lysine N-methyltransferase 3B, Nuclear receptor-binding SET domain-containing protein 1, NR-binding SET domain-containing protein, NSD1, ARA267, KMT3B
Gene Symbols NSD1
Host Species Rabbit
Immunogen Between 650 and 700
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64324
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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