Invitrogen™ NSD2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596870

Catalog No. PIPA596870

Description

Immunogen sequence: MEFSIKQSPL SVQSVVKCIK MKQAPEILGS ANGKTPSCEV NRECSVFLSK AQLSSSLQEG VMQKFNGHDA LPFIPADKLK DLTSRVFNGE PGAHDAKLRF ESQEMKGIGT PPNTTPIKNG SPEIKLKITK TYMNGKPLFE SSICGDSAAD VSQSEENGQK PENKARRNRK RSIKYDSLLE QGLVEAALVS KISSPSDKKI PAKKESCPNT GRDKDHLLKY NVGDLVWSKV SGYPWWPCMV; Positive Samples: HeLa, HepG2, SW620, Mouse brain, Mouse spleen; Cellular Location: Chromosome, Cytoplasm, Nucleus.

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.

Specifications

• Antigen: NSD2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NSD2
• Gene Alias: 5830445G22Rik; 9430010A17Rik; AW555663; C130020C13Rik; D030027O06Rik; D930023B08Rik; Histone-lysine N-methyltransferase NSD2; histone-lysine N-methyltransferase NSD2; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2; IL5 promoter REII region-binding protein; Kiaa1090; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2; mKIAA1090; MMSET; multiple myeloma SET domain containing protein type III; multiple myeloma SET domain-containing protein; NSD2; nuclear receptor binding SET domain protein 2; nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; Protein trithorax-5; putative histone-lysine N-methyltransferase NSD2-like protein; REIIBP; RGD1565590; trithorax/ash1-related protein 5; TRX5; WHS; Whsc1; Whsc1l; Wolf-Hirschhorn syndrome candidate 1; Wolf-Hirschhorn syndrome candidate 1 (human); Wolf-Hirschhorn syndrome candidate 1 protein; Wolf-Hirschhorn syndrome candidate 1 protein homolog
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 107823, 7468
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.81 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O96028, Q8BVE8
• Gene Symbols: NSD2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human WHSC1 (NP_5798771).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG