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Invitrogen™ NSE Polyclonal Antibody
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Catalog No. PIPA129117
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6 mL
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PIPA129117 6 mL
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Catalog No. PIPA129117 Supplier Invitrogen™ Supplier No. PA129117
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: Brain, Pancreas. PA1-29117 has been successfully used in immunohistochemistry (frozen tissue), immunohistochemistry (paraffin tissue) applications.

Neuron specific enolase (NSE, ENO1, ENO2, ENO3) is an enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway, and the reverse reaction in gluconeogenesis. NSE has a high stability in biological fluids and can easily diffuse to the extracellular medium and cerebrospinal fluid (CSF) when neuronal membranes are injured.NSE is one of three mammalian enolases, which are also known as ENO1, ENO2, and ENO3 or alternately as enolase alpha, beta and gamma. The alpha-subunit is expressed in most tissues, the beta-subunit only in muscle, and the gamma-subunit is expressed primarily in neurons, in normal and in neoplastic neuroendocrine cells. Co-expression of NSE and chromogranin A is common in neuroendocrine neoplasms. Since neurons require a great deal of energy, they are very rich in glycolytic enzymes such a GAPDH and NSE. Antibodies to NSE protein are useful to identify neuronal cell bodies, developing neuronal lineage and neuroendocrine cells. Release of NSE from damaged neurons into CSF and blood has also been used as a biomarker of neuronal injury. NSE is used clinically as a sensitive and useful marker of neuronal damage in several neurological disorders including stroke, hypoxic brain damage, status epilepticus, Creutzfeldt-Jakob disease, and herpetic encephalitis. Further, NSE is found in elevated concentrations in plasma and certain neoplasias that include pediatric neuroblastoma and small cell lung cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NSE
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.121 μg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene ENO2
Gene Accession No. P09104
Gene Alias 2-phospho-D-glycerate hydrolyase; 2-phospho-D-glycerate hydro-lyase; AI837106; D6Ertd375e; Eno; ENO2; Eno-2; ENOG; Enolase 2; enolase 2 (gamma, neuronal); enolase 2, gamma neuronal; enolase 2, gamma, neuronal; epididymis secretory protein Li 279; gamma enolase; gamma-enolase; gamma-enolase-like; gamma-subunit of enolase; HEL-S-279; LOC100911625; Neural enolase; neuron specific enolase; neuron specific gamma enolase; Neuronal Enolase; neuronal enriched enolase; neurone-specific enolase; neuron-specific enolase; NSE; RNEN3
Gene Symbols ENO2
Host Species Rabbit
Immunogen Neuron specific enolase (gamma-gamma isoenzyme) isolated from bovine brain.
Purification Method IgG fraction
Quantity 6 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2026, 526006
Target Species Human, Bovine
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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