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Invitrogen™ NSFL1C Polyclonal Antibody
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Catalog No. PIPA5100296
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PIPA5100296 100 μL
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Catalog No. PIPA5100296 Supplier Invitrogen™ Supplier No. PA5100296
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total NSFL1C.

p47, also known as NSFL1C, UBX1, UBXD10 or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the golgi apparatus (specifically to golgi stacks) and contains one SEP domain and one UBX domain. Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP and is required for the fragmentation of golgi stacks during mitosis and for subsequent reassembly of golgi stacks after mitosis. p47 is subject to phosphorylation during mitosis, which inhibits p47-golgi interaction and is, therefore, required for proper golgi stack formation and cisternal regrowth. Human p47 shares 89% sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NSFL1C
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Nsfl1c
Gene Accession No. Q9CZ44, Q9UNZ2
Gene Alias dJ776F14.1; Munc-18c; NSFL1 (p97) cofactor (p47); NSFL1 cofactor; NSFL1 cofactor p47; NSFL1C; p47; p97 cofactor p47; RP4-776F14.2; SHP1 homolog; Stxbp3a; UBX domain-containing protein 2C; UBX1; UBXD10; UBXN2C; XY body-associated protein XY40; XY40
Gene Symbols Nsfl1c
Host Species Rabbit
Immunogen A synthesized peptide derived from human NSFL1C(Accession Q9UNZ2), corresponding to amino acid residues V119-A169.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 386649, 55968
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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