Invitrogen™ NSG1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536497

Catalog No. PIPA536497

Description

This antibody detects endogenous protein at a molecular weight of 21 kDa. Purity is >95% by SDS-PAGE.

NEEP21 (neuron-enriched endosomal 21kDa protein), also known as brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family. It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues. NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons. It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties. In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (Neurotensin receptor 2).

Specifications

• Antigen: NSG1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NSG1
• Gene Alias: brain neuron cytoplasmic protein 1; brain neuron cytoplasmic protein 1/2; brain specific mRNA b; Bsmrb; carboxyterminally EE-tagged neuron-enriched endosomal 21 kDa protein; D4S234; D4S234E; m234; Neep21; neuron specific gene family member 1; Neuronal vesicle trafficking-associated protein 1; Neuron-enriched endosomal protein of 21 kDa; Neuron-specific protein family member 1; NSG1; p21; PEP1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18196, 25247, 27065
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide; pH 7.2
• Gene Accession No.: P02683, P42857, Q62092
• Gene Symbols: NSG1
• Immunogen: Synthetic peptide corresponding to amino acids 130-180 of human NEEP21.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG