Invitrogen™ NSMCE1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590865

Catalog No. PIPA590865

Description

Immunogen sequence: RMGVMTDVHR RFLQLLMTHG VLEEWDVKRL QTHCYKVHDR NATVDKLEDF INNINSVLES LYIEIKRGVT EDDGRPIYAL VNLATTSISK MATDFAENEL DLFRKALELI IDSETGFASS TNILNLVDQL KGKKMRKKEA EQVLQKFVQN KWLIEKEGEF TLHGRAILEM EQYIRETYPD AVKICNICHS LLIQGQSCET CGIRMHLPCV AKYFQSNAEP RCPHCNDYWP HEIPKVFDPE KERESGVLKS NKKSLRSRQH; Positive Samples: BxPC-3, Rat testis; Cellular Location: Chromosome, Nucleus, telomere.

The NSMCE1 (Non-SMC Element 1 Homolog) gene encodes a protein that is a key component of the SMC5-SMC6 complex, which is essential for DNA repair and the maintenance of genomic stability. Located on chromosome 16, the NSMCE1 protein interacts with other components of the SMC5-SMC6 complex, including SMC5, SMC6, and NSMCE2, facilitating the repair of DNA double-strand breaks and promoting chromosome segregation during cell division. NSMCE1 is particularly involved in homologous recombination, a critical pathway for error-free DNA repair. Mutations or deficiencies in NSMCE1 can lead to genomic instability, increased sensitivity to DNA-damaging agents, and have been associated with several genetic disorders and cancer predispositions.

Specifications

• Antigen: NSMCE1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NSMCE1
• Gene Alias: 2510027N19Rik; HSPC333; HSPC337; Non-SMC element 1 homolog; non-SMC element 1 homolog (S. cerevisiae); non-structural maintenance of chromosomes element 1 homolog; NSE1; NSE1 homolog, SMC5-SMC6 complex component; Nsmce1; RGD1307760
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 197370, 361645
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 4.03 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q499U6, Q8WV22
• Gene Symbols: NSMCE1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 7-266 of human NSMCE1 (NP_6595472).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat, Rat
• Product Type: Antibody
• Isotype: IgG