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Invitrogen™ NSUN2 Recombinant Rabbit Monoclonal Antibody (3H24L11)

Catalog No. PI702036
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100 μg
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Catalog No. Quantity
PI702036 100 μg
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Catalog No. PI702036 Supplier Invitrogen™ Supplier No. 702036
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Horse and Mouse Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

NSUN2 encodes a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu(CAA). Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu(CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Mutations of NSUN2 result in autosomal recessive 5 mental retardation (MRT5).
TRUSTED_SUSTAINABILITY

Specifications

Antigen NSUN2
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 3H24L11
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene NSUN2
Gene Accession No. Q08J23
Gene Alias 5-methycytoisine methyltransferase; D13Wsu123e; hTrm4; Misu; mRNA cytosine C(5)-methyltransferase; MRT5; Myc-induced SUN domain containing protein; myc-induced SUN domain-containing protein; Myc-induced SUN-domain-containing protein; NOL1/NOP2/Sun domain family 2; NOL1/NOP2/Sun domain family member 2; NOL1/NOP2/Sun domain family, member 2; NOP2/Sun domain family, member 2; NOP2/Sun RNA methyltransferase family member 2; NOP2/Sun RNA methyltransferase family, member 2; Nsun2; RGD1311954; RNA cytosine C(5)-methyltransferase NSUN2; SAKI; substrate of AIM1/Aurora kinase B; TRM4; tRNA (cytosine(34)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase NSUN2; tRNA cytosine C(5)-methyltransferase; tRNA methyltransferase 4 homolog
Gene Symbols NSUN2
Host Species Rabbit
Immunogen Protein corresponding to Human NSUN2 (aa 350-600).
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54888
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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