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Invitrogen™ NTAL Monoclonal Antibody (NAP-03)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA119327
Description
This antibody recognizes a defined intracellular epitope (aa 196-212) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kDa transmembrane adaptor protein associating with lipid raft components in the plasma membrane of B cells, NK cells and myeloid cells. This antibody will not cross-react with mouse. Western Blot: Incubation 60 min; non-reducing conditions, 12% separating SDS-PAGE gel.
NTAL (Non-T cell Activation Linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Specifications
NTAL | |
Monoclonal | |
1 mg/mL | |
PBS with 15 mM sodium azide; pH 7.4 | |
Q9GZY6 | |
LAT2 | |
Peptide corresponding to aa 196-212 of human NTAL, coupled to KLH. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2a |
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
NAP-03 | |
Unconjugated | |
LAT2 | |
AW125574; HSPC046; LAB; Lat2; LAT-2 like; Linker for activation of B-cells; linker for activation of T cells family, member 2; linker for activation of T cells, transmembrane adaptor 2; linker for activation of T-cells family member 2; Membrane-associated adapter molecule; non-T cell activation linker; non-T-cell activation linker; NTAL; WBS15; WBSCR15; WBSCR5; Williams-Beuren syndrome chromosomal region 15 protein; williams-Beuren syndrome chromosomal region 15 protein homolog; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosome region 5 homolog; Williams-Beuren syndrome chromosome region 5-like protein; WSCR5 | |
Mouse | |
Protein A | |
RUO | |
7462 | |
4°C, do not freeze | |
Liquid |
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