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Invitrogen™ NTAL Monoclonal Antibody (NAP-03)
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Catalog No. 01676083
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100 μg
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Catalog No. Quantity
01-676-083 100 μg
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Catalog No. 01-676-083 Supplier Invitrogen™ Supplier No. MA119327
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Description

Mouse Monoclonal Antibody

This antibody recognizes a defined intracellular epitope (aa 196-212) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kDa transmembrane adaptor protein associating with lipid raft components in the plasma membrane of B cells, NK cells and myeloid cells. This antibody will not cross-react with mouse. Western Blot: Incubation 60 min; non-reducing conditions, 12% separating SDS-PAGE gel.

NTAL (Non-T cell Activation Linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NTAL
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone NAP-03
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15 mM sodium azide; pH 7.4
Gene LAT2
Gene Accession No. Q9GZY6
Gene Alias AW125574; HSPC046; LAB; Lat2; LAT-2 like; Linker for activation of B-cells; linker for activation of T cells family, member 2; linker for activation of T cells, transmembrane adaptor 2; linker for activation of T-cells family member 2; Membrane-associated adapter molecule; non-T cell activation linker; non-T-cell activation linker; NTAL; WBS15; WBSCR15; WBSCR5; Williams-Beuren syndrome chromosomal region 15 protein; williams-Beuren syndrome chromosomal region 15 protein homolog; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosome region 5 homolog; Williams-Beuren syndrome chromosome region 5-like protein; WSCR5
Gene Symbols LAT2
Host Species Mouse
Immunogen Peptide corresponding to aa 196-212 of human NTAL, coupled to KLH.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7462
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2a
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