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Invitrogen™ NTHL1 Polyclonal Antibody
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Catalog No. APPA6506
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200 μL
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APPA6506 200 μL
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Catalog No. APPA6506 Supplier Invitrogen™ Supplier No. PA116506
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Description

Rabbit Polyclonal Antibody

The target sequence has 93% sequence homology with bovine proteins. Suggested positive control: Hela whole cell lysate, K562 cell extracts, Hela cell extracts, K562 whole cell lysate.

Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations. Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA. The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites.A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NTHL1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene NTHL1
Gene Accession No. O35980, P78549
Gene Alias bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase; Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; DNA glycoslyase/AP lyase; DNA glycosylase/AP lyase; Endonuclease III-like protein 1; FAP3; hNTH1; nth (endonuclease III)-like 1 (E.coli); nth endonuclease III-like 1; Nth1; NTHL 1; Nthl1; nth-like DNA glycosylase 1; OCTS 3; OCTS3; thymine glycol DNA glycosylase/AP lyase
Gene Symbols NTHL1
Host Species Rabbit
Immunogen A peptide derived from human NTH1, conjugated to KLH.
Purification Method Antigen affinity chromatography
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18207, 29541, 4913
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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