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Invitrogen™ NTN3 Polyclonal Antibody
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Catalog No. PIPA547110
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100 μg
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PIPA547110 100 μg
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Catalog No. PIPA547110 Supplier Invitrogen™ Supplier No. PA547110
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Description

Goat Polyclonal Antibody

In direct ELISAs, approximately 10% cross-reactivity with recombinant chicken Netrin-1 is observed and less than 1% cross-reactivity with recombinant human Netrin-4, recombinant mouse (rm) Netrin-G1a and rmNetrin-G2a is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Netrin-3 (NTN3) is a gene located on chromosome 16q22.1, encoding a protein that belongs to the netrin family of secreted molecules crucial for axon guidance and cell signaling in nervous system development. NTN3 is primarily expressed in the central nervous system, where it functions as a guidance cue for developing neurons, influencing processes such as axon attraction or repulsion and the establishment of neural networks. The protein interacts with specific receptors on neuronal growth cones to mediate directional movement and synapse formation. Beyond its role in neural development, NTN3 is involved in tissue morphogenesis and cellular migration in other physiological contexts. Aberrant expression or mutations in NTN3 can lead to developmental disorders and neurodegenerative conditions due to impaired neural pathway formation. Research into NTN3 continues to explore its therapeutic potential for enhancing neural repair and regeneration in pathological states.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NTN3
Applications Neutralization, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene NTN3
Gene Accession No. Q90923
Gene Alias netrin 1; netrin 3; netrin-2; Netrin-2, chicken, homolog of, like; netrin-2-like protein; Netrin-3; NTN1; NTN2; NTN2L; Ntn3
Gene Symbols NTN3
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant chicken Netrin-2 Ala16-Pro581.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 396387
Target Species Chicken
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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