NTRK2 Mouse anti-Human, Clone: OTI2E1, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA500386S

Catalog No. 50-167-1521

Description

TrkB is a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). TrkB is involved in the development and maintece of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.

Specifications

• Antigen: NTRK2
• Classification: Monoclonal
• Concentration: 1.17 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q16620
• Gene Symbols: NTRK2
• Immunogen: Full-length protein expressed in 293T cell transfected with human NTRK2 expression vector
• Quantity: 30 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2E1
• Conjugate: Unconjugated
• Gene: NTRK2
• Gene Alias: EIEE58, GP145-TrkB, OBHD, TRKB, trk-B
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4915
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid