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NTRK2 Mouse anti-Human, Clone: OTI2E1, liquid, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA500386S

Encompass_Preferred

Catalog No. 50-167-1521


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Description

Description

TrkB is a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). TrkB is involved in the development and maintece of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.
Specifications

Specifications

NTRK2
Monoclonal
1.17 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q16620
NTRK2
Full-length protein expressed in 293T cell transfected with human NTRK2 expression vector
30 μL
Primary
Human
Antibody
IgG1
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI2E1
Unconjugated
NTRK2
EIEE58, GP145-TrkB, OBHD, TRKB, trk-B
Mouse
Affinity Chromatography
RUO
4915
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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