Invitrogen™ NTSR2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA3300

Catalog No. APS300

Description

PA3-300 detects neurotensin receptor NTS2 from human samples. PA3-300 has been successfully used in Western blot and immunohistochemistry (paraffin) procedures. By Western blot this antibody detects a ~55-60 kDa protein representing NTS2 receptor. The PA3-300 immunogen is a synthetic peptide corresponding to residues P(381) Q S P T L M D T A S G F G D P P E T R T(401) of human NTS2 receptor.

The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.

Specifications

• Antigen: NTSR2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NTSR2
• Gene Alias: High-affinity levocabastine-sensitive neurotensin receptor; levocabastine-sensitive neurotensin receptor; low affinity neurotensin receptor; low-affinity levocabastine-sensitive neurotensin receptor; neurotensin receptor 2; neurotensin receptor type 2; neurotensin receptor, type 2; NT2 receptor; NT2R; NTR2; NT-R-2; NTR2 receptor; NTRL; Ntsr2
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: Conc. Not Determined
• Formulation: Whole serum with 0.05% sodium azide
• Gene Accession No.: O95665
• Gene Symbols: NTSR2
• Immunogen: Synthetic peptide corresponding to residues P(381) Q S P T L M D T A S G F G D P P E T R T(401) of human NTS2 receptor.
• Regulatory Status: RUO
• Gene ID (Entrez): 23620
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid