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Tocris Bioscience™ nTZDpa

Catalog No. 215010R
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Catalog No. Quantity
21-501-0R 10 mg
21-505-0 50 mg
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Catalog No. 21-501-0R Supplier Tocris Bioscience™ Supplier No. 2150/10
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Description

Potent, selective PPARγ partial agonist

nTZDpa is a potent, selective non-thiazolidinedione PPARγ partial agonist (EC50 = 57 nM); produces ∽25% maximum efficacy. Antagonizes full agonist activity by ∽60% (IC50 ∽ 285 nM). Displays no activity at PPARα or PPARδ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo.

Specifications

Quantity 10 mg
Product Type nTZDpa
Molecular Weight (g/mol) 428.33
Inhibitors nTZDpa

For Research Use Only

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