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Invitrogen™ NUAK2 Polyclonal Antibody
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Catalog No. PIPA582371
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100 μL
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PIPA582371 100 μL
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Catalog No. PIPA582371 Supplier Invitrogen™ Supplier No. PA582371
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DPKEQKPPQA SGLLLHRKGI LKLNGKFSQT ALELAAPTTF GSLDELAPPR PLARASRPSG AVSEDSILSS ESFDQLDLPE RLPEPPLRGC VSVDNLTGLE EPPSEGPGSC LRRWRQDPLG DSCFSLTDCQ EVTATYRQAL RVCSKLT Highest antigen sequence indentity to the following orthologs: Rat - 81%, Mouse - 81%.

NUAK2 or SNF1/AMP kinase-related kinase (SNARK) is a member of the NUAK family of SNF1-like kinase 2. NUAK2 is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle (1). NUAK2 is involved in cellular stress responses linked to obesity and type 2 diabetes. NUAK2 shows kinase activity against a synthetic test peptide and the activity in keratinocytes is increased by AMP and 5-amino-4-imidazolecarboxamide riboside, implying that AMPK kinase-dependent pathway can activate NAUK2. Glucose deprivation also increases NAUK2 activity in baby hamster kidney fibroblasts.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NUAK2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Nuak2
Gene Accession No. Q9H093
Gene Alias 1200013B22Rik; EMBL:AAH81899.1}; mKIAA0537; NUAK family kinase 2; NUAK family SNF1-like kinase 2; NUAK family, SNF1-like kinase, 2; NUAK2; nuak2 {ECO:0000312; Omphalocele kinase 2; Omphk2; SNARK; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; SNF1/AMP-activated protein kinase; UV126
Gene Symbols Nuak2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human NUAK2. Recombinant protein control fragment (Product #RP-89800).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 81788
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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