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Nucleolar protein 3 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501987713
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50-198-7713 100 μL
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Catalog No. 50-198-7713 Supplier Bioss Supplier No. BS7080R
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Description

Rabbit Polyclonal Antibody

ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms. Isoform 1 is involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. ARC inhibits extrinsic apoptotic pathways two different ways. The first is by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. The second way is by interacting with CASP8 in a mitochondria localization-and phosphorylation-dependent manner, which in turn limits the amount of soluble CASP8 avaliable for DISC-mediated activation. ARC also inhibits intrinsic apoptotic pathways in response to a wide range of stresses through interactions with BAX. This results in BAX inactivation and prevents mitochondrial dysfunction and release of pro-apoptotic factors. Mutations affecting the gene can results in myoclonus, familiam cortical.

Specifications

Antigen Nucleolar protein 3
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene NOL3
Gene Accession No. O60936
Gene Alias Apoptosis repressor with CARD; Arc; B430311C09Rik; FCM; Muscle-enriched cytoplasmic protein; MYC; Myp; NOL3; NOP; Nop 30; Nop30; Nucleolar protein 3; nucleolar protein 3 (apoptosis repressor with CARD domain); Nucleolar protein of 30 kDa
Gene Symbols NOL3
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from mouse Nucleolar protein 3/Apoptosis repressor with CARD.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8996
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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