Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Nudel Mouse anti-Human, Mouse, Clone: OTI5E11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525658

Catalog No. PIMA525658


Add to cart

Description

Description

Nudel was initially discovered as a protein homologous to Aspergillus NUDE and that associated with Lis1 and polyprotein complex cytoplasmic dynein, both of which have been linked to neuronal development and migration. It was later shown to be a substrate of cdk5, a kinase known to be critical during neuronal migration; phosphorylation of Nudel by cdk5 affects its localization in neurons and affects neuritic morphology. It is thought that together with Lis1, Nudel regulates cytoplasmic dynein, a large polyprotein complex, in neuronal migration and mitosis through direct interactions. Similar interactions are thought to also play a role in membrane traffic in other cells as disruption of Nudel expression through RNA interference perturbed normal endomembrane flux and resulted in the fragmentation of the Golgi apparatus.
Specifications

Specifications

Nudel
Monoclonal
0.6 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9ERR1, Q9GZM8
NDEL1; nudE nuclear distribution gene E homolog (A. nidulans)-like 1; DKFZp451M0318; EOPA; MITAP1; NUDEL; NUDE-like protein; endooligopeptidase A; mitosin-associated protein MITAP1; nudE nuclear distribution gene E homolog like 1
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
81565, 83431
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI5E11
Unconjugated
NDEL1
Liquid
Ndel1
Full length human recombit protein of NDEL1 produced in HEk293 cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Mouse
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit