Invitrogen™ NUDT15 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558614

Catalog No. PIPA558614

Description

Immunogen sequence: EKENYHYVTI LMKGEVDVTH DSEPKNVEPE KNESWEWVPW EELPPLDQLF WGLRCLKEQG YDPFKEDLNH LVGYKGNHL Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.

Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.

Specifications

• Antigen: NUDT15
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NUDT15
• Gene Alias: 6530403O17; 7,8-dihydro-8-oxoguanine-triphosphatase NUDT15; 8-oxo-dGTPase NUDT15; A730068G11Rik; mMTH2; MTH2; MutT homolog 2; nucleoside diphosphate-linked moiety X motif 15; Nucleoside diphosphate-linked to another moiety X hydrolase 15; Nucleotide triphosphate diphosphatase NUDT15; nudix (nucleoside diphosphate linked moiety X)-type motif 15; nudix hydrolase 15; Nudix motif 15; nudix-type motif 15; NUDT15; NUDT15D; probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; probable 8-oxo-dGTP diphosphatase NUDT15; RP11-90M2.1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55270
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NV35
• Gene Symbols: NUDT15
• Immunogen: Recombinant protein corresponding to Human NUDT15. Recombinant protein control fragment (Product #RP-102861).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG